Coordination of fingertip forces during precision grip in premanifest Huntington's disease
Identifieur interne : 001735 ( Main/Exploration ); précédent : 001734; suivant : 001736Coordination of fingertip forces during precision grip in premanifest Huntington's disease
Auteurs : Ashwini K. Rao [États-Unis] ; Andrew M. Gordon [États-Unis] ; Karen S. Marder [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-04.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Cognition Disorders (etiology), Coordination, Disability Evaluation, Female, Fingers (physiopathology), Force, Hand Strength (physiology), Humans, Huntington Disease (complications), Huntington Disease (pathology), Huntington disease, Huntington's disease, Male, Middle Aged, Motor Skills Disorders (etiology), Motor control, Nervous system diseases, Neuropsychological Tests, Predictive Value of Tests, Psychomotor Performance (physiology), Weight Lifting (physiology), motor control, precision grip, premanifest.
- MESH :
- complications : Huntington Disease.
- etiology : Cognition Disorders, Motor Skills Disorders.
- pathology : Huntington Disease.
- physiology : Hand Strength, Psychomotor Performance, Weight Lifting.
- physiopathology : Fingers.
- Adult, Disability Evaluation, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Predictive Value of Tests.
Abstract
Precision grip control is important for accurate object manipulation and requires coordination between horizontal (grip) and vertical (load) fingertip forces. Manifest Huntington's disease (HD) subjects demonstrate excessive and highly variable grip force and delayed coordination between grip and load forces. Because the onset of these impairments is unknown, we examined precision grip control in premanifest HD (pre‐HD) subjects. Fifteen pre‐HD and 15 age‐ and sex‐matched controls performed the precision grip task in a seated position. Subjects grasped and lifted an object instrumented with a force transducer that measured horizontal grip and vertical load forces. Outcomes were preload time, loading time, maximum grip force, mean static grip force, and variability for all measures. We compared outcomes across groups and correlated grip measures with the Unified Huntington's Disease Rating Scale and predicted age of onset. Variability of maximum grip force (P < .0001) and variability of static grip force (P < .00001) were higher for pre‐HD subjects. Preload time (P < .007) and variability of preload time (P < .006) were higher in pre‐HD subjects. No differences were seen in loading time across groups. Variability of static grip force (r2 = 0.23) and variability of preload time (r2 = 0.59) increased with predicted onset and were correlated with tests of cognitive function. Our results indicate that pre‐HD patients have poor regulation of the transition between reach and grasp and higher variability in force application and temporal coordination during the precision grip task. Force and temporal variability may be good markers of disease severity because they were correlated with predicted onset of disease. © 2011 Movement Disorder Society
Url:
- https://api.istex.fr/document/EE13BA096706479A63F54ED94D1ABF701894EF7D/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116202
DOI: 10.1002/mds.23606
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-04">2011-04</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="862">862</biblScope><biblScope unit="page" to="869">869</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">EE13BA096706479A63F54ED94D1ABF701894EF7D</idno><idno type="DOI">10.1002/mds.23606</idno><idno type="ArticleID">MDS23606</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cognition Disorders (etiology)</term><term>Coordination</term><term>Disability Evaluation</term><term>Female</term><term>Fingers (physiopathology)</term><term>Force</term><term>Hand Strength (physiology)</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington Disease (pathology)</term><term>Huntington disease</term><term>Huntington's disease</term><term>Male</term><term>Middle Aged</term><term>Motor Skills Disorders (etiology)</term><term>Motor control</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Predictive Value of Tests</term><term>Psychomotor Performance (physiology)</term><term>Weight Lifting (physiology)</term><term>motor control</term><term>precision grip</term><term>premanifest</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Motor Skills Disorders</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hand Strength</term><term>Psychomotor Performance</term><term>Weight Lifting</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Fingers</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Predictive Value of Tests</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chorée de Huntington</term><term>Contrôle moteur</term><term>Coordination</term><term>Force</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Precision grip control is important for accurate object manipulation and requires coordination between horizontal (grip) and vertical (load) fingertip forces. Manifest Huntington's disease (HD) subjects demonstrate excessive and highly variable grip force and delayed coordination between grip and load forces. Because the onset of these impairments is unknown, we examined precision grip control in premanifest HD (pre‐HD) subjects. Fifteen pre‐HD and 15 age‐ and sex‐matched controls performed the precision grip task in a seated position. Subjects grasped and lifted an object instrumented with a force transducer that measured horizontal grip and vertical load forces. Outcomes were preload time, loading time, maximum grip force, mean static grip force, and variability for all measures. We compared outcomes across groups and correlated grip measures with the Unified Huntington's Disease Rating Scale and predicted age of onset. Variability of maximum grip force (P < .0001) and variability of static grip force (P < .00001) were higher for pre‐HD subjects. Preload time (P < .007) and variability of preload time (P < .006) were higher in pre‐HD subjects. No differences were seen in loading time across groups. Variability of static grip force (r2 = 0.23) and variability of preload time (r2 = 0.59) increased with predicted onset and were correlated with tests of cognitive function. Our results indicate that pre‐HD patients have poor regulation of the transition between reach and grasp and higher variability in force application and temporal coordination during the precision grip task. Force and temporal variability may be good markers of disease severity because they were correlated with predicted onset of disease. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Rao, Ashwini K" sort="Rao, Ashwini K" uniqKey="Rao A" first="Ashwini K." last="Rao">Ashwini K. Rao</name></region><name sortKey="Gordon, Andrew M" sort="Gordon, Andrew M" uniqKey="Gordon A" first="Andrew M." last="Gordon">Andrew M. Gordon</name><name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S." last="Marder">Karen S. Marder</name><name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S." last="Marder">Karen S. Marder</name><name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S." last="Marder">Karen S. Marder</name><name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S." last="Marder">Karen S. Marder</name><name sortKey="Rao, Ashwini K" sort="Rao, Ashwini K" uniqKey="Rao A" first="Ashwini K." last="Rao">Ashwini K. Rao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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